“Miosis is a medical term for constriction of the pupil. It is the
opposite of mydriasis. It is seen in a variety of medical conditions,
and can also be caused by certain drugs and chemicals. Eye drops used
to intentionally cause miosis are known as “miotics“. Extreme miosis is
commonly called “pinpoint pupils“, a situation that can be caused by
use of opiates.”
“Heroin can be administered several ways, including snorting and
injection, and may be smoked by inhaling its vapors when heated, i.e.
“chasing the dragon“.
Some users mix heroin with cocaine in a “speedball” or “snowball” that
usually is injected intravenously, smoked, or dissolved in water and
then snorted, producing a more intense rush than heroin alone, but is
more dangerous because the combination of the short-acting stimulant
with the longer-acting depressant increases the risk of overdose with
one or both drugs.
A combination which is either snorted or “parachuted” (orally ingested
in a piece of paper, capsule, etc) of Tylenol PM (paracetamol with
diphenhydramine) is known as “cheese” or “Tylenol With Smack“.
Once in the brain, heroin is rapidly metabolized to morphine by removal
of the acetyl groups, thus is as a prodrug; the morphine molecule then
binds with opioid receptors, inducing the subjective, heroin high.
The onset of heroin’s effects depends upon the method of
–Orally, heroin is completely metabolized in vivo to
morphine before crossing the blood-brain barrier; the effects are the
same as with oral morphine.
–Snorting results in an onset within 3 to 5
–Smoking results in an almost immediate, 7 to 11 seconds,
milder effect that strengthens;
–Intravenous injection induces a rush
and euphoria in 30 to 60 seconds; intramuscular and subcutaneous
injection take effect within 3 to 5 minutes.”
* Relief of Extreme Pain
* Pain relief
* Cough suppressant
* Barbiturates and Benzodiazepines
* Other opioids (depends heavily on tolerance)
* Respiratory arrest, seizure, coma, death
* Spontaneous abortion
Central nervous system:
Cardiovascular & Respiratory:
* Lowered heart rate
* Weak pulse
* Shallow breathing
* Respiratory depression
Eyes, Ears, nose, and mouth:
* Dry mouth
* Pupil constriction (“pinpoint pupils”)
* Miosis (constriction of pupils; opposite of mydriasis)
* Vomiting (protracted)
* Urinary retention
* Muscle spasticity
* Analgesia (colloquially known as a painkiller)
* Physical dependence
* Anxiolysis (a drug prescribed for the treatment of symptoms of anxiety.)
* Psychological dependence
* Somnolence (a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods)
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